Endocrine Abstracts

Background: Radioiodine (RAI) is widely used for the treatment of hyperthyroidism. Most patients respond to RAI therapy with a normalization of TFTs and improvement in clinical symptoms within 4–8 weeks. Hypothyroidism may occur from 4 weeks on, with 40% of patients being hypothyroid by 8 weeks and >80% by 16 weeks. American thyroid association guidelines recommend testing for free T4, total T3, and TSH within the first 1–2 months after RAI. Biochemical monitorin...

NAD+, an essential coenzyme in energy production, has recently risen to prominence as a signalling molecule central in mediating cellular metabolism and mitochondrial function. NAD+ dependent protein deacetylase sirtuin (SIRT) proteins regulate key metabolic transcription factors, including FOXOs and PGC-1α in muscle, in response to cellular energy demands and metabolic stress. Declining NAD+, metabolic and mitochondrial function are hallm...

Avascular necrosis is a rare presenting feature of endogenous hypercortisolism. The literature suggests that, if left untreated, complete collapse of the femoral head may ensue, necessitating hip replacement in up to 70% of patients. The majority of described patients with avascular necrosis due to endogenous hypercortisolaemia were treated surgically.Case report: A 36-year-old female, investigated for right leg pain, reported rapid weight gain, easy bru...

The aim of the reported study was to assess gene expression levels of the OPG/RANK/RANKL system in peripheral blood mononuclear cells (PBMC) after tibolone and hormonal replacement therapy (HRT) administered to patients with oestrogen deficiency symptoms and osteopenia or postmenopausal osteoporosis.Material and methods: 74 women after menopause, aged 45–71 years, were enrolled into the study and randomly assigned to different medical therapies: HRT...

The aim of this study was to evaluate quantitative changes in OPG and RANKL proteins after tibolone and hormonal replacement therapy (HRT) administered to patients with oestrogen deficiency symptoms and osteopenia or postmenopausal osteoporosis.Material and methods: A total of 74 women after menopause, aged 45–71 years, patients of the Outpatient Clinic of Osteoporosis of the Military Teaching Hospital in Lodz, were enrolled into the study. The pati...

Introduction/objective: To evaluate the effects of estroprogestagen therapy (EP) on the mineral bone density (BMD) of girls with functional hypothalamic amenorrhea (FHA).Design: Prospective observation of 78 FHA girls subjected to 4-year EP therapy (Group A) and 50 controls (Group C).Methods: Anthropometric measurements (height, body weight) were taken for all participants along with baseline values of hormonal parameters and bone ...

Introduction: The pleiotropic effects of vitamin D extend to control many physiological and pathophysiological processes in the human body. One of them is involved in the protective process of the nerve cells during stroke as well as pathogenesis of type 2 diabetes. Serum 25-hydroxyvitamin D concentration <20 ng/ml indicating vitamin D deficiency which is common in Poland. The aim of this study was to estimate serum level of 25-hydroxyvitamin D in acute ischemic strokes&#1...

Aim: To assess lipid levels in patients with PCOS and normal body weight.Materials and methods: 139 patients admitted to the Gynaecologic Endocrinology Clinic of the Jagiellonian University’s Collegium Medicum agreed to take part in this research, and PCOS, according to the Rotterdam criteria, was found in 96 of them. The control group consisted of 43 patients with FAI <5. All of the 96 patients had a normal (BMI <25) body weight. This index...

Aim: To assess lipid levels in patients with PCOS and BMI >25.Materials and methods: 102 patients admitted to the Gynaecologic Endocrinology Clinic of the Jagiellonian University’s Collegium Medicum agreed to take part in this research, and PCOS, according to the Rotterdam criteria, was found in 87 of them. The control group consisted of 15 patients with FAI <5. All of the 87 patients had BMI >25. This index, as well as blood samples, we...

Introduction: Secondary hyperthyroidism due to thyrotropin-secreting pituitary adenoma (TSHoma) is rare. Coexistence of TSHoma and primary thyroid disease that could lead to hyperthyroidism is even more unusual.Case report: A 28-year-old female with longstanding and worsening symptoms of hyperthyroidism was admitted to the hospital. Free-T4 (32.89 pmol/l) and free-T3 (6.38 pg/ml) were elevated with moderately increased TSH level (5....